Collagen-boosting TCM herb may hold the answer to preventing bone loss

c7e00bd1-7015-4177-9cb3-6e51c005e9fcarticleimage.jpg

30 Aug 2017 --- An herb used in Traditional Chinese medicine (TCM) might be crucial to a new osteoporosis therapy that could prevent bone loss without causing side effects, according to a new study by researchers at the University of British Columbia (UBC). 

Using a compound derived from red sage, known as Danshen in Chinese, UBC researchers have found a way to selectively block an enzyme called Cathepsin K (CatK), which plays a major role in the breakdown of collagen in bones during osteoporosis. The researchers’ findings have been published in the Journal of Bone and Mineral Research

Osteoporosis is a global health problem that will affect one out of three women and one out of five men worldwide, and there is a multibillion-dollar pharmaceutical industry dedicated to finding treatments to stop its progression, according to UBC’s press release.

“The development of osteoporosis drugs by pharmaceutical companies has focused heavily on blocking CatK in recent years,” says Dieter Brömme, a professor in the faculty of dentistry and a Canada Research Chair in Proteases and Disease of previous efforts. “All clinical trials to date have failed due to side effects ranging from stroke, skin fibrosis and cardiovascular issues. We've found a way to block CatK only in bone tissue that we think will prevent these other negative effects.”

Compound holds key
The researchers tested a compound derived from red sage in human and mouse bone cells and a mouse model. They found that it prevented bone loss and increased the bone mineral density of the mice treated with the compound by 35 percent when compared with the control group.

The study builds on previous research by Brömme and his team that looked at the effectiveness of red sage, used to treat bone ailments in traditional Chinese medicine, in stopping the activity of CatK in limited ways.

Enzyme blockers work like keys in locks, notes UBC’s press release. Most drugs in development have been so called active site-directed inhibitors, which act like master keys and lock the entire enzyme, blocking both its disease-relevant functions such as collagen degradation and its other normal functions.

“CatK is a multifunctional enzyme with important roles in other parts of the body and we think completely blocking it is what causes unexpected side effects in other drugs,” explains Preety Panwar, a research associate in the Brömme lab. “Our compound only locks the collagen-degrading CatK activity, preventing the unregulated breakdown of collagen in bones without any other negative impacts.”

The treatment could also potentially be used to treat a variety of other bone and cartilage diseases such as arthritis and certain bone cancers.

To contact our editorial team please email us at editorial@cnsmedia.com

Related Articles

Nutrition & Health News

Targeting aching joints: A key theme at Vitafoods Europe 2018

21 May 2018 --- World populations are getting older and with age, the risk of bone and joint health issues – such as rheumatoid arthritis and osteoarthritis – increases. Moreover, joint health concerns also affect younger consumers, such as so-called “weekend warriors,” who exercise once or twice a week, meaning that the joint health market is of interest not just to senior citizens but also to any consumers seeking to live an active life. Among the different innovative healthy aging and lifestyle solutions presented at Vitafoods Europe this year, there was a clear spot for ingredients aimed at supporting joint health.

Nutrition & Health News

Protein provides benefit for adult bone and joint health, expert consensus reports

17 May 2018 --- Dietary protein intake above the recommended levels may help reduce bone loss and fracture risk in seniors with osteoporosis, an expert consensus reports. Based on an analysis of major research studies, the review, published in Osteoporosis International, found that a protein-rich diet is beneficial for adult bone health. The consensus debunks the popular myth that too much protein may be damaging to bone health.

Nutrition & Health News

Golden spice: Turmeric finds appeal in organic NPD

11 May 2018 --- Touting a vast array of health benefits, turmeric has been trending for quite some months now. The golden spice was one of the standout trends at Vitafoods Europe 2017, and it has since made its way into a wide range of food and beverages launched over the past year. The application of turmeric was a standout theme at this year’s Natural and Organic Products show in London held the end of April. NutritionInsight looks at some of the offerings on show.

Nutrition & Health News

One gram of fish oil a day to keep osteoarthritis pain at bay, study suggests

10 May 2018 --- One gram of fish oil a day could help reduce the pain of patients with osteoarthritis, a new study in Rheumatology reports. In the largest, most up to date study of its kind, researchers from the University of Surrey examined the link between diet and the effective self-management of osteoarthritis.

Nutrition & Health News

Essential oils, kombucha and hemp to take center stage at Vitafoods Europe 2018

10 May 2018 --- Emerging ingredients for health and nutrition will be a key focus at the 2018 edition of Vitafoods Europe which takes place in Palexpo, Geneva next week. A new R&D stream entitled Up and Coming featuring in the event’s Education Program will cater for this revised focus. Notably, essential oils, kombucha and industrial hemp will be in the spotlight.

More Articles
URL : http://www.nutritioninsight.com:80/news/collagen-boosting-tcm-herb-may-hold-the-answer-to-preventing-bone-loss.html