Personalised Genome Weight Loss Programs May Be Coming Soon

11 Jan 2016 ---  Some health experts predict that the next big advance in helping overweight people achieve a healthier weight will be to use an individual's genetic data to customize diets and physical activity plans, an approach known as "precision weight loss."

Some health experts predict that the next big advance in helping overweight people achieve a healthier weight will be to use an individual's genetic data to customize diets and physical activity plans, an approach known as "precision weight loss." A recent summary report on the genetics of weight loss, developed by some of the leading experts in this field, finds that the biggest challenge to realizing this dream is the need for better analytical tools for discovering the relationships between genetics, behavior and weight-related diseases.
 
The report, which appears in the January edition of the journal Obesity, summarizes what scientists currently know about factors that influence weight loss and weight regain, and it identifies how genetic information and data collection from non-invasive, portable devices may soon be incorporated into research and weight loss treatment.
 
"I think within five years, we'll see people start to use a combination of genetic, behavioral and other sophisticated data to develop individualized weight management plans," says Molly Bray, a geneticist and professor of nutritional sciences at The University of Texas at Austin, who led the working group.
 
Bray speculates that in the future, patients might submit saliva samples for gene sequencing, along with using automated sensors to collect information about factors such as their environment, diet, activity and stress. A computer algorithm would take this information and provide patients with specific recommendations to achieve their target weight.
 
Bray says the falling cost of genome sequencing, plus portable monitors (such as Fitbit) to track in real time people's behavior and environment, mean that scientists already have the ability to collect the kinds of data they need to do the fundamental research behind precision weight loss. According to the study, the real challenge now for researchers is to develop the tools to analyze this flood of data.
 
"We are pretty good at helping people lose weight in the short term," says Bray. "But the stats on long-term weight loss are pretty dismal. We still don't understand the process of weight regain very well, either from a behavioral or a biological standpoint."
 
Scientists have uncovered some of the genetic basis for weight-related diseases, such as the discovery of a gene that appears to cause energy from food to be stored as fat rather than be burned. Some reporters have dubbed it the "obesity gene," but Bray cautions that it's not so simple.
 
"When you go back and see how much of the variation in this gene accounts for the variation in body size in the general population, it's really small," says Bray. "So that highlights that there are going to be several genes involved with obesity, and they're going to interact with each other in complicated ways. And that's certainly true of weight loss and maintenance too."
 
Obesity puts a large burden on the health care system and increases an individual's risk for a number of other diseases including diabetes, cardiovascular disease and cancer. It's also rising at an alarming rate around the world.
 
"Obesity is one of the gravest problems of our times," says Bray. "Obviously prevention would be the best approach, but there are literally millions of individuals who are currently obese and are in dire need of more effective strategies for long-term weight loss that will ultimately improve overall health."
 
Multiple research projects have shown that about half of the variation in people’s body mass index can be attributed to genetic factors, while the rest is due to environmental factors, including diet and exercise. For example, depending on a person's specific genetic makeup, exercise might be less effective at reducing weight for some people compared with others.
 
"When people hear that genes may be playing a role in their weight loss success, they don't say, 'Oh great, I just won't exercise anymore,'" says Bray. "They actually say 'Oh thank you. Finally someone acknowledges that it's harder work for me than it is for others.' And then I think they're a little more forgiving of themselves, and they're more motivated to make a change.”
 
This report grew out of a workshop convened by the National Institutes of Health in 2014 titled "Genes, Behaviors, and Response to Weight Loss Interventions." It synthesizes a broad range of research from institutions around the world.
 
"We've made great strides in our understanding of what drives eating behavior, how fat cells are formed and how metabolism is altered before and after the onset of obesity," says Bray. "The time is ripe to take this wealth of data and find ways to utilize it more effectively to treat people in need." 

Source: Obesity 

To contact our editorial team please email us at editorial@cnsmedia.com

Related Articles

Nutrition & Health News

MenaQ7 Full Spectrum K2 closest ingredient to dietary cheese intake, study finds

20 Apr 2018 --- Based on a global state of vitamin K2 deficiency and the strong evidence showing it is a cardio-protective nutrient, researchers recommend cheese as a component of a heart-healthy diet due to its vitamin K2 content. However, for those unable to consume enough cheese daily, NattoPharma has introduced its MenaQ7 Full Spectrum K2, which aims to deliver the range of menaquinones found in foods.

Nutrition & Health News

Infant food allergy linked to genetics and skin exposure to food, dust and wipes

19 Apr 2018 --- Food allergy is triggered by perfect storm of genetics and skin exposure to infant wipes, dust and food, according to a new Northwestern Medicine study. Infant and childhood food allergy, whose cause has long been a mystery, has now been linked to a mix of environmental and genetic factors that must coexist to trigger the allergy. The factors contributing to food allergy include the genetics that alter skin absorbency, use of infant cleansing wipes that leave soap on the skin, skin exposure to allergens in dust and skin exposure to food from those providing infant care. Food allergy is triggered when these factors occur together.

Nutrition & Health News

Plant-based possibilities: Report details novel sugar replacements for beverages

19 Apr 2018 --- PreScouter, a Chicago based technology scouting company, details novel replacements for sugars in a new analysis, that are from natural sources, safe, technologically viable and environmentally stable, for use in beverages. The company hopes that the report answers consumer calls for sweeteners that are both natural and healthy, in light of diabetes and obesity epidemics, and that it may aid informing beverage providers on how to best respond to calls for lowering sugar levels in drinks.

Nutrition & Health News

Probiotic peanut allergy treatment: Chr. Hansen enters new partnership

18 Apr 2018 --- Probiotic strain, LGG, can potentially play a part in peanut allergy treatment. Prota Therapeutics, developer of oral immunotherapies to treat food allergies, has partnered with Chr. Hansen, Danish food ingredients producer, to assess LGG in a clinical trial to develop a treatment for the allergy. Chr. Hansen tells NutritionInsight that the partnership is in effect as from today, and strengthens the position of Chr. Hansen in a market expected to grow to €10billion by 2025.

Nutrition & Health News

Beneo's functional carbohydrate gains Argentinian approval 

16 Apr 2018 --- Beneo’s Palatinose functional carbohydrate (isomaltulose) has been approved for use in all food and drink categories in Argentina, the company has reported. Palatinose is naturally-sourced and delivers full carbohydrate energy (4kcal/g) in a more balanced way, due to a slower and more sustained uptake. This results in higher fat oxidation and a low glycemic effect which can aid diet-related problems such as obesity and diabetes.

More Articles
URL : http://www.nutritioninsight.com:80/news/Personalised-Genome-Weight-Loss-Programs-May-Be-Coming-Soon.html?tracking=Nutrition%20and%20Health%20News