Omega-6 fatty acids promote prostate tumor cell growth

02 Aug 2005 --- A study has demonstrated that omega-6 fatty acids such as the fat found in corn oil promote the growth of prostate tumor cells in the laboratory.

A study conducted at the San Francisco VA Medical Center (SFVAMC) has demonstrated that omega-6 fatty acids such as the fat found in corn oil promote the growth of prostate tumor cells in the laboratory. The study also identifies a potential new molecular target for anti-tumor drugs: an enzyme known as cPLA2, which plays a key role in the chain leading from omega-6 fatty acids to prostate tumor cell growth.

The study was led by Millie Hughes-Fulford, PhD, director of the Laboratory of Cell Growth at SFVAMC and scientific advisor to the U.S. Undersecretary of Health for the Department of Veterans Affairs. It is being published in the September 2005 issue of Carcinogenesis, and is currently available online.

Working with human prostate cancer cells in tissue culture, Hughes-Fulford and her fellow researchers identified for the first time a direct chain of causation: When introduced into prostate tumor cells in culture, omega-6 fatty acid causes the production of cPLA2, which then causes the production of the enzyme COX2. In turn, COX2 stimulates the release of PGE2, a hormone-like molecule that promotes cell growth.

The study points out that 60 years ago in the United States, the dietary ratio of omega-6 to omega-3, a beneficial fatty acid, was 1 to 2. Today, the ratio is 25 to 1. Over that same 60 years, the incidence of prostate cancer in the U.S. has increased steadily.

The research was funded by awards from the U.S. Department of Veterans Affairs and in part by grants from the National Aeronautics and Space Administration. Funding was administered by the Northern California Institute for Research and Education (NCIRE).

To contact our editorial team please email us at editorial@cnsmedia.com

Related Articles

Nutrition & Health News

Weekly Digest: Omega 3 fatty acids health halo widens, NP Nutra organics line gets green boost

20 Apr 2018 --- The past seven days in the Nutrition world has seen research findings suggesting that omega 3 fatty acid supplementation could protect against the potential negative outcomes of smoking during pregnancy, such a preterm birth. Regarding new product launches, Nature’s Power Nutraceuticals corp (NP Nutra) has added two new powders to their sustainable, organic, green ingredients line in honor of world Earth day; Cambridge Commodities has released a customizable range of vitamin and mineral blends, coined Blendev, and off the back of successful product launches this year, Rousselot and Peptan commit to future innovations through customer engagement days. Lastly, Lycored has released its innovative plans for engaging customers at Vitafoods: with an interactive installation which tells the story of lycopene, a carotenoid found in tomatoes.

Nutrition & Health News

Plant-based possibilities: Report details novel sugar replacements for beverages

19 Apr 2018 --- PreScouter, a Chicago based technology scouting company, details novel replacements for sugars in a new analysis, that are from natural sources, safe, technologically viable and environmentally stable, for use in beverages. The company hopes that the report answers consumer calls for sweeteners that are both natural and healthy, in light of diabetes and obesity epidemics, and that it may aid informing beverage providers on how to best respond to calls for lowering sugar levels in drinks.

Nutrition & Health News

Anlit launches “fun and tasty” omega 3 chew for pregnant women

18 Apr 2018 --- Producers of high-quality children’s dietary supplements, Anlit, have launched "tasty", high-DHA omega 3 chewable supplements for pregnant and breastfeeding women. 

Nutrition & Health News

UK: Boots urged to ditch krill products amid Greenpeace concerns

17 Apr 2018 --- UK pharmacy-led health and beauty chain Boots has come under fire for selling krill products which threaten Antarctic wildlife with Greenpeace claiming stocks are being plundered for krill oil and omega 3 tablets. 

Nutrition & Health News

“New superfood”: Alfalfa ingredient steps up on sustainability

17 Apr 2018 --- Luzixeen, developed by L-RD (Luzerne (Alfalfa – Research & Development) have integrated an innovative technical approach to their biorefinery process, which enables the entire alfalfa crop to be used. The process of valirsation makes it possible to take advantage of the total plant, which is local to France. Luzixeen is based on sustainable farming of the local alfalfa, and they tout the environmental benefits of the eco-compatible culture which they also hail as a “new superfood.”

More Articles
URL : http://www.nutritioninsight.com:80/news/Omega-6-fatty-acids-promote-prostate-tumor-cell-growth.html