Omega-6 fatty acids promote prostate tumor cell growth

02 Aug 2005 --- A study has demonstrated that omega-6 fatty acids such as the fat found in corn oil promote the growth of prostate tumor cells in the laboratory.

A study conducted at the San Francisco VA Medical Center (SFVAMC) has demonstrated that omega-6 fatty acids such as the fat found in corn oil promote the growth of prostate tumor cells in the laboratory. The study also identifies a potential new molecular target for anti-tumor drugs: an enzyme known as cPLA2, which plays a key role in the chain leading from omega-6 fatty acids to prostate tumor cell growth.

The study was led by Millie Hughes-Fulford, PhD, director of the Laboratory of Cell Growth at SFVAMC and scientific advisor to the U.S. Undersecretary of Health for the Department of Veterans Affairs. It is being published in the September 2005 issue of Carcinogenesis, and is currently available online.

Working with human prostate cancer cells in tissue culture, Hughes-Fulford and her fellow researchers identified for the first time a direct chain of causation: When introduced into prostate tumor cells in culture, omega-6 fatty acid causes the production of cPLA2, which then causes the production of the enzyme COX2. In turn, COX2 stimulates the release of PGE2, a hormone-like molecule that promotes cell growth.

The study points out that 60 years ago in the United States, the dietary ratio of omega-6 to omega-3, a beneficial fatty acid, was 1 to 2. Today, the ratio is 25 to 1. Over that same 60 years, the incidence of prostate cancer in the U.S. has increased steadily.

The research was funded by awards from the U.S. Department of Veterans Affairs and in part by grants from the National Aeronautics and Space Administration. Funding was administered by the Northern California Institute for Research and Education (NCIRE).

Related Articles

Nutrition & Health News

Drink your vitamins: SternVitamin launches micronutrient premix for beverages 

19 Feb 2018 --- A healthy lifestyle is essential to all age groups, and nutrition plays a major role alongside various other components. SternVitamin is now offering beverage manufacturers a novel way to address the topic of health with a new micronutrient premix for healthy bones and heart. SternVitamin notes that the mix picks up on one of the top trends in the beverage market – water-based enriched products. The vegan premix contains vitamins B1, B12, C, K2 and D3. Organic agave syrup powder gives it a slight sweetness, while natural flavors give the drink a “dark berry” taste. It dissolves clear in water and leaves no turbidity. 

Nutrition & Health News

Research driving demand for OPO in China’s formula market: Advanced Lipids

16 Feb 2018 --- OPO is increasing in popularity in China’s infant formula market, and according to Advanced Lipids, this is down to the growing body of scientific research backing the benefits of this ingredient. Also known as SN-2 palmitate, OPO is a premium quality ingredient that mimics the fatty acid profile of human milk.

Business News

Natures Crops, De Wit Speciality Oils enter into European distribution partnership for Ahiflower oil

15 Feb 2018 --- Natures Crops International and De Wit Speciality Oils have entered into a distribution agreement for Ahiflower oil in the European dietary supplement marketplace. This alliance is thought to add strategic value for both companies through each company’s leading position in manufacturing and marketing nutraceutical products.

Nutrition & Health News

A gold medal for recovery? FrieslandCampina DMV develops innovative casein isolate 

14 Feb 2018 --- FrieslandCampina DMV has introduced their latest innovation in dairy protein ingredients. Micelate Prestige has been launched this week in Europe and is a key addition to the company’s growing portfolio of Performance Nutrition solutions. 

Nutrition & Health News

L-Carnitine – "Unquestionable" room for market growth: Lonza

08 Feb 2018 --- From facilitating the recovery process in the sports nutrition sector to improving energy metabolism in healthy aging products, L-Carnitine has proven itself a versatile ingredient with the potential to be applied in myriad applications. “Sports nutrition, weight management, all these areas are still growing. There is no question that there is a lot of room for L-Carnitine’s development. We see a lot of demand coming from Asia and Africa for infant food applications. The other big market is for sure energy drinks,” Marco Gossen, Business Development Manager at Lonza, explains during a NutritionInsight webinar last week, looking at product development and untapped opportunities for L-Carnitine.

More Articles
URL : http://www.nutritioninsight.com:80/news/Omega-6-fatty-acids-promote-prostate-tumor-cell-growth.html