Omega-6 fatty acids promote prostate tumor cell growth

02 Aug 2005 --- A study has demonstrated that omega-6 fatty acids such as the fat found in corn oil promote the growth of prostate tumor cells in the laboratory.

02/08/05 A study conducted at the San Francisco VA Medical Center (SFVAMC) has demonstrated that omega-6 fatty acids such as the fat found in corn oil promote the growth of prostate tumor cells in the laboratory. The study also identifies a potential new molecular target for anti-tumor drugs: an enzyme known as cPLA2, which plays a key role in the chain leading from omega-6 fatty acids to prostate tumor cell growth.

The study was led by Millie Hughes-Fulford, PhD, director of the Laboratory of Cell Growth at SFVAMC and scientific advisor to the U.S. Undersecretary of Health for the Department of Veterans Affairs. It is being published in the September 2005 issue of Carcinogenesis, and is currently available online.

Working with human prostate cancer cells in tissue culture, Hughes-Fulford and her fellow researchers identified for the first time a direct chain of causation: When introduced into prostate tumor cells in culture, omega-6 fatty acid causes the production of cPLA2, which then causes the production of the enzyme COX2. In turn, COX2 stimulates the release of PGE2, a hormone-like molecule that promotes cell growth.

The study points out that 60 years ago in the United States, the dietary ratio of omega-6 to omega-3, a beneficial fatty acid, was 1 to 2. Today, the ratio is 25 to 1. Over that same 60 years, the incidence of prostate cancer in the U.S. has increased steadily.

The research was funded by awards from the U.S. Department of Veterans Affairs and in part by grants from the National Aeronautics and Space Administration. Funding was administered by the Northern California Institute for Research and Education (NCIRE).

Related Articles

Nutrition & Health News

World Digestive Health Day Highlights Dietary Solutions to IBD

29 May 2017 --- With Inflammatory Bowel Diseases (IBD) affecting more than 2.5 million people in Europe and one in four in the US, consumers are increasingly interested in food and ingredients that support a healthy digestive system. This year's World Digestive Health Day (WDHD), organized by the World Gastroenterology Organisation (WGO) and the WGO Foundation, draws attention to IBD and the various therapies currently being developed to treat these diseases, including dietary supplements to improve the microbiome in the gut.

Nutrition & Health News

DuPont Probiotic Strain Recorded for Foods with Function Claims in Japan

29 May 2017 --- Food products containing Bifidobacterium lactis HN019 from the DuPont Danisco range have recently been recorded with the Japanese Consumer Affairs Agency for Food with Function Claims. Currently, drinkable yogurts, yogurts and dietary supplements containing HN019 as a functional ingredient have been recognized for claims such as the improvement of microflora and defecation for those suffering from constipation by adjusting intestinal environments. 

Nutrition & Health News

Obesity Contributes to Cardiovascular Ill-Health, Even in Young People

29 May 2017 --- Although higher than normal body mass index (BMI) is known to lead to cardiovascular ill-health in mid-to-late life, there has been limited investigation of its effect in young, apparently healthy, adults. Researchers have now shown that having a higher BMI can cause worse cardiovascular health in those aged as young as 17, according to a study presented at the annual conference of the European Society of Human Genetics on Sunday.

Nutrition & Health News

CSIRO Presents Intermittent Fasting "Flexi" Diet

29 May 2017 --- Australia's Commonwealth Scientific and Industrial Research Organisation (CSIRO) has launched a new diet that includes intermittent fasting three days a week. The weight loss program is based on research carried out by CSIRO scientists who found that fasting can be an effective way to lose weight and stay healthy.

Nutrition & Health News

Study Finds Consumption of Lean Pork Aids Weight Loss and Healthy Aging

26 May 2017 --- Including nutrient-rich lean pork as part of a weight-loss diet could help women achieve their weight-loss success and improve their ability to get around, according to new research published in Current Developments in Nutrition. 

More Articles
URL : http://www.nutritioninsight.com:80/news/Omega-6-fatty-acids-promote-prostate-tumor-cell-growth.html