Mechanism Affecting Vitamin K2 in Health Conditions Revealed in New Review

636022746728631696564.jpg

23 Jun 2016 --- New research has found that vitamin K2 impairment by common drugs may cause CVD, and that statins and warfarin share the same mechanism that causes CVD and diabetes.

Leading vitamin K2 research and development company NattoPharma ASA has revealed new research findings from their multi-year research and development program to substantiate and discover the health benefits of vitamin K2 for applications in the marketplace for functional food and dietary supplements.
 
The findings, published in the journal Pharmacology, examine the positive associations observed between cardiovascular disease (CVD) and Type 2 diabetes mellitus (DM), and the negative effect of medications prescribed to both groups of patients share a common mechanism:  to inhibit vitamin K2-dependent processes, which was interpreted to lead to increased onset of CVD, DM, chronic kidney disease, bone fracture, and even mental disorder.
 
Okuyama et al., the authors of the review paper "Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes,” note that impaired vitamin K2-dependent processes by some types of vegetable oils and medicines, but not plasma high low-density lipoprotein cholesterol, were proposed as the cause of CVD, DM and other lifestyle-related diseases.
 
"Once again the scientific community recognizes that the inhibition of vitamin K2 synthesis by common medications carries serious, newly recognized repurcussions,” says Hogne Vik, Chief Medical Officer with NattoPharma, adding that while it has been well known for some time that statins inhibit CoQ10, a 2015 review paper finally highlighted that statins also inhibit K2 synthesis.
 
”Recognized Vitamin K2 antagonists significantly inhibit Vitamin K activity outside the liver with serious, unintended consequences.”
 
The function of K vitamins is unique among other vitamins and important throughout all life stages. Vitamin K2 activates proteins that are made in different organs in the body – clotting factors in the liver, osteocalcin in bones, and Matrix Gla Protein (MGP) in the vasculature. These proteins help coagulate blood, bind calcium to the surface of bones, and keep calcium from depositing in the arteries and soft tissues.
 
While the function of Vitamin K2 is vital to ensuring that the body properly utilizes calcium, studies have shown that 97 percent of Western populations are Vitamin K2 deficient/insufficient. 
 
"We are not only finally seeing recognition that Vitamin K2 is woefully insufficient in the diet, but the is a growing body of evidence that pharmaceuticals further exacerbate the problem of our limited Vitamin K2 status, delivering potentially dangerous consequences for human health,” Vik concluded.
 
MenaQ7 is the best documented, commercially available vitamin K2 as MK-7 with guaranteed actives and stability, clinical substantiation, and international patents granted and pending. MenaQ7 is available in two varieties: natural vitamin K2 as MK-7 Crystals and nature-identical synthetic vitamin K2 as MK-7 PURE.
 
References:
1 Okuyama H et al. Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes. Pharmacology 2016;98:134–170. DOI: 10.1159/000446704.
2 Okuyama H et al. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Rev Clin Pharmacol. 2015 Mar;8(2):189-99. doi: 10.1586/17512433.2015.1011125. Epub 2015 Feb 6.
3  Shea MK et al. Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults. J Nutr. 2011 Aug;141(8):1529-34.

To contact our editorial team please email us at editorial@cnsmedia.com

Related Articles

Nutrition & Health News

Shifting OTC landscape: P&G acquires Merck’s consumer health unit in US$4.2bn deal

20 Apr 2018 --- Procter & Gamble (P&G) has acquired Merck KGaA’s, Darmstadt, Germany, consumer health unit in a US$4.2 billion acquisition that hopes to boost P&G’s health care capabilities, such as with vitamins and supplements, and give them a stronger foothold in global markets.

Nutrition & Health News

MenaQ7 Full Spectrum K2 closest ingredient to dietary cheese intake, study finds

20 Apr 2018 --- Based on a global state of vitamin K2 deficiency and the strong evidence showing it is a cardio-protective nutrient, researchers recommend cheese as a component of a heart-healthy diet due to its vitamin K2 content. However, for those unable to consume enough cheese daily, NattoPharma has introduced its MenaQ7 Full Spectrum K2, which aims to deliver the range of menaquinones found in foods.

Nutrition & Health News

Weekly Digest: Omega 3 fatty acids health halo widens, NP Nutra organics line gets green boost

20 Apr 2018 --- The past seven days in the Nutrition world has seen research findings suggesting that omega 3 fatty acid supplementation could protect against the potential negative outcomes of smoking during pregnancy, such a preterm birth. Regarding new product launches, Nature’s Power Nutraceuticals corp (NP Nutra) has added two new powders to their sustainable, organic, green ingredients line in honor of world Earth day; Cambridge Commodities has released a customizable range of vitamin and mineral blends, coined Blendev, and off the back of successful product launches this year, Rousselot and Peptan commit to future innovations through customer engagement days. Lastly, Lycored has released its innovative plans for engaging customers at Vitafoods: with an interactive installation which tells the story of lycopene, a carotenoid found in tomatoes.

Nutrition & Health News

Bone and joint health: Consumer demands and promising ingredients

19 Apr 2018 --- Mobility, which incorporates bone and joint health, is becoming a key concern for a range of demographics. NutritionInsight spoke with a number of key suppliers in the bone and joint health space about the key ingredients to look out for, as well as some key consumer demands driving innovation in this space.

Nutrition & Health News

Infant food allergy linked to genetics and skin exposure to food, dust and wipes

19 Apr 2018 --- Food allergy is triggered by perfect storm of genetics and skin exposure to infant wipes, dust and food, according to a new Northwestern Medicine study. Infant and childhood food allergy, whose cause has long been a mystery, has now been linked to a mix of environmental and genetic factors that must coexist to trigger the allergy. The factors contributing to food allergy include the genetics that alter skin absorbency, use of infant cleansing wipes that leave soap on the skin, skin exposure to allergens in dust and skin exposure to food from those providing infant care. Food allergy is triggered when these factors occur together.

More Articles
URL : http://www.nutritioninsight.com:80/news/Mechanism-Affecting-Vitamin-K2-in-Health-Conditions-Revealed-in-New-Review.html