High Fructose Consumption Linked to Increase of Liver Disease in Young Consumers

b4813027-ce8f-41dc-831f-ee311c0b3a53articleimage.jpg

14 Feb 2017 --- Researchers from the UK and Italy have suggested that high levels of dietary fructose and uric acid may be key in the development of poor liver health amongst children and adolescents.

They say high fructose intake may increase serum uric acid concentrations, and that both uric acid concentration and fructose consumption may be increased in individuals with non-alcoholic fatty liver disease (NAFLD).

Investigators also say they have established that fructose intake is independently associated with non-alcoholic steatohepatitis (NASH). Their conclusions are published in the Journal of Hepatology.

NAFLD, the accumulation of extra fat in liver cells in people who drink little or no alcohol, is recognized as the fastest growing cause of liver disease in both Western and developing countries.

It is estimated to affect up to 30% of the general population in Western countries and up to 9.6% of all children and 38% of obese children across a spectrum of liver disease, including NASH (defined as steatosis, hepatocyte ballooning and inflammation).

Although NASH is a less aggressive form of NAFLD, it can progress to severe fibrosis and cirrhosis, with development of hepatocellular carcinoma in adults.

“It is plausible that dietary fructose intake and uric acid concentrations are potential risk factors for liver disease progression in NAFLD,” explained senior investigator Valerio Nobili, MD, Chief of the Hepatometabolic Unit Liver Diseases Laboratory, Bambino Gesù Hospital, IRCCS, Rome, Italy.

“Numerous studies have shown that high uric acid levels are associated with metabolic syndrome and NAFLD, but to date, to the best of our knowledge, no studies have tested the independence of associations among uric acid concentrations, fructose consumption, and NASH confirmed by biopsy.”

A team of researchers in Italy and the UK studied 271 obese children and adolescents with NAFLD (155 males, mean age 12.5 years) who underwent liver biopsy.

All patients completed a food frequency questionnaire, indicating when specific foods were consumed (breakfast, morning snack, lunch, afternoon snack, dinner, etc.), how often (every day of the week, sometimes, or never), and portion size.

Major sources of dietary fructose among children and adolescents are soda and other sweetened beverages.

Nearly 90% reported drinking sodas and soft drinks one or more times a week.

Almost 95% of patients regularly consumed morning and afternoon snacks consisting of crackers, pizza and salty food, biscuits, yogurt, or other snacks.

In the group of patients studied, 37.6% of patients had NASH and 47% of patients with NASH had high uric acid compared with 29.7% of patients who did not have NASH.

Fructose consumption was independently associated with high uric acid, which occurred more frequently in patients with NASH than in not-NASH patients.

“In this study, we show for the first time that uric acid concentrations and dietary fructose consumption are independently and positively associated with NASH.”

“The development of NASH may markedly affect life expectancy and quality of life in affected individuals and therefore it is crucial to understand the risk factors for NASH in children and adolescents in order to design effective interventions which can be used safely to treat this young group of patients,” Dr. Nobili concluded.

The researchers say that efforts geared towards behavior modification, nutrition education, and limiting access to soda and other sweetened beverages could potentially reduce fructose consumption in this particular population.

Related Articles

Nutrition & Health News

BASF targets fatty liver disease with US launch of Hepaxa product

23 Feb 2018 --- BASF is launching Hepaxa to help patients manage non-alcoholic fatty liver disease in what the corporation describes as “the first dedicated product in the US” to potentially assist tens of millions of patients with one of the most common forms of chronic liver disease. And it could begin to “turn around” non-alcoholic fatty liver disease (NAFLD) in as little as six months, according to BASF executives. 

Nutrition & Health News

Low-fat and low-carb diets equally effective, Stanford study finds

21 Feb 2018 --- After years of debate, a new study at the Stanford University School of Medicine has found that neither a low-fat nor a low-carb diet is superior: Cutting either carbs or fats leads to a reduction of excess weight in about the same proportion, according to the study. The study also looked into whether insulin levels or a specific genotype pattern could predict an individual's success on either diet. The answer, in both cases, was no.

Nutrition & Health News

Low-carb diet found to help battle fatty liver disease

20 Feb 2018 --- A carbohydrate-restricted diet can lead to “rapid and dramatic” reductions of liver fat and other cardiometabolic risk factors, along with marked decreases in the synthesis of hepatic fat, reveals a study published last week in Cell Metabolism. The study results could lead to improved treatments for non-alcoholic fatty liver disease (NAFLD). 

Nutrition & Health News

Yogurt may reduce cardiovascular disease risk

19 Feb 2018 --- A higher yogurt intake is associated with lower cardiovascular disease risk among hypertensive men and women, a study in the American Journal of Hypertension suggests. High blood pressure is a major cardiovascular disease risk factor. Clinical trials have previously demonstrated beneficial effects of dairy consumption on cardiovascular health, and yogurt may independently be related to cardiovascular disease risk.

Nutrition & Health News

Drink your vitamins: SternVitamin launches micronutrient premix for beverages 

19 Feb 2018 --- A healthy lifestyle is essential to all age groups, and nutrition plays a major role alongside various other components. SternVitamin is now offering beverage manufacturers a novel way to address the topic of health with a new micronutrient premix for healthy bones and heart. SternVitamin notes that the mix picks up on one of the top trends in the beverage market – water-based enriched products. The vegan premix contains vitamins B1, B12, C, K2 and D3. Organic agave syrup powder gives it a slight sweetness, while natural flavors give the drink a “dark berry” taste. It dissolves clear in water and leaves no turbidity. 

More Articles
URL : http://www.nutritioninsight.com:80/news/High-Fructose-Consumption-Linked-to-Increase-of-Liver-Disease-in-Young-Consumers.html?tracking=Nutrition%20and%20Health%20News