High Fructose Consumption Linked to Increase of Liver Disease in Young Consumers

b4813027-ce8f-41dc-831f-ee311c0b3a53articleimage.jpg

14 Feb 2017 --- Researchers from the UK and Italy have suggested that high levels of dietary fructose and uric acid may be key in the development of poor liver health amongst children and adolescents.

They say high fructose intake may increase serum uric acid concentrations, and that both uric acid concentration and fructose consumption may be increased in individuals with non-alcoholic fatty liver disease (NAFLD).

Investigators also say they have established that fructose intake is independently associated with non-alcoholic steatohepatitis (NASH). Their conclusions are published in the Journal of Hepatology.

NAFLD, the accumulation of extra fat in liver cells in people who drink little or no alcohol, is recognized as the fastest growing cause of liver disease in both Western and developing countries.

It is estimated to affect up to 30% of the general population in Western countries and up to 9.6% of all children and 38% of obese children across a spectrum of liver disease, including NASH (defined as steatosis, hepatocyte ballooning and inflammation).

Although NASH is a less aggressive form of NAFLD, it can progress to severe fibrosis and cirrhosis, with development of hepatocellular carcinoma in adults.

“It is plausible that dietary fructose intake and uric acid concentrations are potential risk factors for liver disease progression in NAFLD,” explained senior investigator Valerio Nobili, MD, Chief of the Hepatometabolic Unit Liver Diseases Laboratory, Bambino Gesù Hospital, IRCCS, Rome, Italy.

“Numerous studies have shown that high uric acid levels are associated with metabolic syndrome and NAFLD, but to date, to the best of our knowledge, no studies have tested the independence of associations among uric acid concentrations, fructose consumption, and NASH confirmed by biopsy.”

A team of researchers in Italy and the UK studied 271 obese children and adolescents with NAFLD (155 males, mean age 12.5 years) who underwent liver biopsy.

All patients completed a food frequency questionnaire, indicating when specific foods were consumed (breakfast, morning snack, lunch, afternoon snack, dinner, etc.), how often (every day of the week, sometimes, or never), and portion size.

Major sources of dietary fructose among children and adolescents are soda and other sweetened beverages.

Nearly 90% reported drinking sodas and soft drinks one or more times a week.

Almost 95% of patients regularly consumed morning and afternoon snacks consisting of crackers, pizza and salty food, biscuits, yogurt, or other snacks.

In the group of patients studied, 37.6% of patients had NASH and 47% of patients with NASH had high uric acid compared with 29.7% of patients who did not have NASH.

Fructose consumption was independently associated with high uric acid, which occurred more frequently in patients with NASH than in not-NASH patients.

“In this study, we show for the first time that uric acid concentrations and dietary fructose consumption are independently and positively associated with NASH.”

“The development of NASH may markedly affect life expectancy and quality of life in affected individuals and therefore it is crucial to understand the risk factors for NASH in children and adolescents in order to design effective interventions which can be used safely to treat this young group of patients,” Dr. Nobili concluded.

The researchers say that efforts geared towards behavior modification, nutrition education, and limiting access to soda and other sweetened beverages could potentially reduce fructose consumption in this particular population.

Related Articles

Nutrition & Health News

Chronic Fatigue Syndrome Linked to Imbalanced Microbiome

26 Apr 2017 --- Scientists have discovered abnormal levels of specific gut bacteria related to chronic fatigue syndrome/myalgic encephalomyelitis, or ME/CFS, in patients with and without concurrent irritable bowel syndrome (IBS). The findings come from researchers at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health.

Nutrition & Health News

SGS Approved to Audit Against the Gluten-Free Certification Organization Standard

26 Apr 2017 --- SGS, the world’s leading inspection, verification, testing and certification company has been approved as the first Certification Body to audit against the Gluten-Free Certification Organization (GFCO) standards covering all regions of the world.

Nutrition & Health News

Glanbia Introduces Lecithin-Free Agglomeration Technology

26 Apr 2017 --- Glanbia Nutritionals has announced a breakthrough patent-pending agglomeration technology called BevEdge for powdered drink mixes and liquid beverages. Entirely lecithin free, this method of agglomeration is based on an all-protein solution and can be applied to whey-based, milk-based, casein-based and plant-based ingredients, including hydrolysates. This flexibility provides both sports and lifestyle brands with significantly more opportunities to create highly marketable beverages. And with no lecithin, it is a perfect clean label solution.

Nutrition & Health News

Low Fat, High Sugar "Diet" Products Contribute to Weight Gain: US Study

26 Apr 2017 --- A new study has underscored the idea that low fat, high sugar "diet" foods play an important role in unwanted weight gain. Researchers from the University of Georgia found that rats fed a diet high in sugar but low in fat increased body fat mass when compared to rats fed a balanced (rodent) diet. Moreover, the rats fed a high-sugar diet were more likely to experience a range of other health problems, such as liver damage and brain inflammation.

Nutrition & Health News

Colitis Relieving Properties Turmeric Extract BCM-95 Underlined by Study

26 Apr 2017 --- A study has found that while standard curcumin does possess anti-inflammatory properties, BCM-95, a high-potency turmeric extract, is significantly more effective than standard curcumin in reducing colitis related disease activity and inflammatory symptoms. BCM-95 is a proprietary formulation of Arjuna Natural Extracts in a joint venture with Dolcas Biotech LLC and is composed of pure curcuminoids and essential oils from turmeric with a specific content of turmerones.

More Articles
URL : http://www.nutritioninsight.com:80/news/High-Fructose-Consumption-Linked-to-Increase-of-Liver-Disease-in-Young-Consumers.html?tracking=Nutrition%20and%20Health%20News